CAlgary SAlt for Postural Orthostatic Tachycardia Syndrome Study
Many patients with postural orthostatic tachycardia syndrome (POTS) have decreased plasma volume. Current POTS guidelines recommend \ 10 g of salt and 2-3 L of fluid per day. Despite this recommendation, there is no long term data evaluating the use of salt in POTS. This randomized, placebo-controlled cross-over trial will evaluate a high salt diet, compared to a normal salt diet over a period of 3 months. Participants will complete 3 in lab evaluations including autonomic function testing, tilt table testing, blood volume and urine sodium evaluation, plasma catecholamine measurements and and cytokine measurements.
• Physician Diagnosis of POTS as defined by the CCS Consensus Statement and as follows:
• Sustained, excessive orthostatic tachycardia ≥ 30 bpm within 10 minutes standing.
• Absence of orthostatic hypotension (\>20/10 mmHg decrease) within 3 minutes standing.
• Chronic orthostatic symptoms that improve with recumbence.
• Age 18-60 years old.
• Ability to attend the Calgary Autonomic Research Clinic in Calgary.
• Resident of Canada